As the COVID-19 pandemic continues to devastate the world, researchers and scientists are working tirelessly to find creative and effective ways to curb the spread and impact of the virus—one is stem cell therapy.
The clinical application of stem cells in cellular therapies and regenerative medicine is well-documented. Stem cells have also been suggested as a possible cell therapy for lung-related diseases. This therapy makes their use as a treatment for the coronavirus a viable avenue of research.
How Does Stem Cell Therapy for Coronavirus Work?
SARS-CoV-2, the virus that causes the COVID-19, triggers a lung infection and induces a cell-mediated inflammatory response. Runaway inflammation caused by an overreacting immune system is associated with organ failure, difficulty breathing, and even death in critical cases of COVID-19.
It is hypothesized that stem cells, particularly mesenchymal stem cells (MSCs), could help modulate hyperinflammatory and overactive immune processes. Mesenchymal stem cells are found in the umbilical cord and human tissues. A high differentiation and proliferative capacity characterize them.
Previous studies show that MSCs have immunomodulatory, tissue repair, antimicrobial, and anti-inflammatory properties that alter the adaptive and innate immune responses. But can MSCs therapy help treat COVID-19? Some recent clinical trials on the safety and efficacy of stem cell therapy in COVID-19 patients offer promising results.
Stem Cells Might be a Plausible COVID-19 Treatment
In a study published in Stem Cells Translational Medicine, a group of researchers affiliated with the University of Miami used stem cell therapy on a group of COVID-19 patients diagnosed with severe lung inflammation.
The researchers administered an intravenous infusion of Mesenchymal stem cells from umbilical cord tissue to control the inflammation. The Phase I/IIa clinical trial findings suggested that stem cell therapy in COVID-19 was safe, and the treatment significantly improved patient survival and recovery time.
The results from the study by University of Miami researchers are in line with a Phase 1 clinical trial appearing in Signal Transduction and Targeted Therapy. This earlier study by researchers from China’s National Clinical Research Center for Infectious Diseases concluded that “intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well-tolerated.”
What does all this mean? Although it is too early to say anything for sure regarding the real-world applicability of stem cells as an effective treatment for coronavirus, emerging findings are promising. The potential has been seen. In Charlotte stem cell therapy experts are found at NeoGenix by calling 704-727-6551.